Predicting hospital admissions from individual patient data (IPD): an applied example to explore key elements driving external validity

Objective To explore factors that potentially impact external validation performance while developing and validating a prognostic model for hospital admissions (HAs) in complex read more older general practice patients.Study design and setting Using individual participant data from four cluster-randomised trials conducted in the Netherlands and Ger

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Unwarranted Exclusion of Intermediate Lineage A-B SARS-CoV-2 Genomes Is Inconsistent with the Two-Spillover Hypothesis of the Origin of COVID-19

Pekar et al.(2022) propose that SARS-CoV-2 was a zoonotic spillover that first infected humans in the Huanan Seafood Market in Wuhan, China.They propose that there were two separate spillovers of the closely related lineages A and lineage B in a short period of time.The two lineages are differentiated by two SNVs; hence, a single-SNV A-B intermedia

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Longitudinal analysis of the Five Sisters hot springs in Yellowstone National Park reveals a dynamic thermoalkaline environment

Abstract Research focused on microbial populations of thermoalkaline springs has been driven in a large part by the lure of discovering functional enzymes with industrial applications in high-pH and high temperature environments.While several studies have focused on understanding the fundamental ecology of these springs, the iphone 14 price san fra

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